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Indication & Dosage |
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| Intravenous |
| REVERSAL OF NEUROMUSCULAR BLOCKADE |
| Adult:
200 mcg for each 1 mg of neostigmine or 5 mg of pyridostigmine. Alternatively, 5-15 mcg/kg with 50 mcg/kg neostigmine with 25-70 mcg/kg of neostigmine or 0.1-0.3 mg/kg of pyridostigmine. |
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| Oral |
| PEPTIC ULCER |
| Adult:
1-2 mg bid-tid. |
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| Intravenous |
| REVERSAL OF NEUROMUSCULAR BLOCKADE |
| Child:
10 mcg/kg with 50 mcg/kg neostigmine. |
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| Parenteral |
| REDUCTION OF SECRETIONS |
| Adult:
1-2 mg bid-tid. |
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| Parenteral |
| REDUCTION OF SECRETIONS |
| Child:
1-2 mg bid-tid. |
| Max Dosage: Adult: 400 mcg/dose. Child >1 mth: 200 mcg/dose |
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| Parenteral |
| PEPTIC ULCER |
| Adult:
1-2 mg bid-tid. |
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| Precautions |
Pregnancy, lactation. CV disease, hyperthyroidism, hepatic or renal impairment. Enlarged prostate, diarrhoea, fever. May cause ileus or megacolon in patients with ulcerative colitis. Children and elderly. |
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Potentially Life-threatening
Adverse Drug Reactions |
Xerostomia; loss of taste, nausea, vomiting, constipation, reduced sweating; urinary hesitancy and retention; blurred vision; cycloplegia; increased ocular tension; tachycardia; palpitation; headache, anxiety, bloated feeling, impotence, skin reactions. |
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| Adverse Drug Reactions |
Severe anaphylaxis. |
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| Interactions |
SCOLINEDecreases levodopa effects. Effects may be enhanced by using drugs with antimuscarinic properties or MAOIs concurrently. May antagonise the GI effects of cisapride, metoclopramide and dompeidone. |
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